Article
Is there a genetic basis for the deposition of beta-amyloid after fatal head injury?
Cellular and molecular neurobiology - 1 Feb 1999
Graham D I, Gentleman S M, Nicoll J A, Royston M C, McKenzie J E, Roberts G W, Mrak R E, Griffin W S
Abstract excerpt
1. Alzheimer's disease is a heterogeneous disorder that may be caused by genetic or environmental factors or by a combination of both. Abnormalities in chromosomes 1, 14, and 21 have all been implicated in the pathogenesis of the early-onset form of the disease, while the epsilon 4 allele of the apolipoprotein E gene (on chromosome 19) is now recognized as a risk factor for early- and late-onset sporadic and...
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