Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease.

doi:10.1212/wnl.45.3.555

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Article

Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer's disease.

Neurology - 1 Mar 1995

Mayeux R, Ottman R, Maestre G, Ngai C, Tang M X, Ginsberg H, Chun M, Tycko B, Shelanski M

Abstract excerpt

The apolipoprotein-epsilon 4 allele increases the risk of Alzheimer's disease (AD), but cerebral deposition of beta-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolip...

Topics

Aged
Aged, 80 and over
Alleles
Alzheimer Disease
Apolipoprotein E4
Apolipoproteins E
Brain Injuries
DNA
Female
Genetic Markers
Humans
Male
Risk Factors

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