Article
Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury.
Nature medicine - 1 Feb 1995
Nicoll J A, Roberts G W, Graham D I
Abstract excerpt
Deposition of amyloid beta-protein (A beta) in the brain plays a key role in the pathogenesis of Alzheimer's disease. Apolipoprotein E epsilon 4 allele (apo E-epsilon 4) is a strong risk factor for Alzheimer's disease, and there is in vitro evidence that apo E is directly involved in A beta deposition. Head injury is an epidemiological risk factor for Alzheimer's disease and deposition of A beta occurs in...
Topics
- Adolescent
- Adult
- Age Factors
- Aged
- Alleles
- Alzheimer Disease
- Amyloid beta-Peptides
- Apolipoprotein E4
- Apolipoproteins E
- Cerebral Cortex
- Craniocerebral Trauma
- Gene Dosage