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Article

Inhibition of poly(ADP-ribose) polymerase activity is insufficient to induce tetraploidy.

Nucleic acids research - 1 Feb 2001

Simbulan-Rosenthal C M, Rosenthal D S, Luo R, Li J H, Zhang J, Smulson M E

Abstract excerpt

Poly(ADP-ribose) polymerase (PARP) knockout mice are resistant to murine models of human diseases such as cerebral and myocardial ischemia, traumatic brain injury, diabetes, Parkinsonism, endotoxic shock and arthritis, implicating PARP in the pathogenesis of these diseases. Potent selective PARP inhibitors are therefore being evaluated as novel therapeutic agents in the treatment of these diseases. Inhibition or...

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PMID: 11160908
DOI: 10.1093/nar/29.3.841
PMCID: PMC30380

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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