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Article

[Pituitary specific transcription factor Pit-1/GHF-1 and combined pituitary hormone deficiency].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994

Tatsumi K

Abstract excerpt

Pit-1/GHF-1 is a pituitary-specific POU-domain DNA binding factor, which binds to, and trans-activates the promoters of both growth hormone (GH) and prolactin (PRL) genes. It is well conserved among vertebrates and is indispensable for both differentiation and proliferation of the somatotrophs, lactotrophs and thyrotrophs. PIT1 abnormality is defined as a genetic abnormality in the PIT1 gene, and results in...

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Source

Identifiers

PMID: 8196186

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.Semantic proximity Read ↗

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