[Pituitary specific transcription factor Pit-1/GHF-1 and combined pituitary hormone deficiency].

Article

[Pituitary specific transcription factor Pit-1/GHF-1 and combined pituitary hormone deficiency].

Nihon rinsho. Japanese journal of clinical medicine - 1 Apr 1994

Tatsumi K

Abstract excerpt

Pit-1/GHF-1 is a pituitary-specific POU-domain DNA binding factor, which binds to, and trans-activates the promoters of both growth hormone (GH) and prolactin (PRL) genes. It is well conserved among vertebrates and is indispensable for both differentiation and proliferation of the somatotrophs, l...

Topics

Animals
DNA-Binding Proteins
Growth Hormone
Humans
Mutation
Prolactin
Thyrotropin
Transcription Factor Pit-1
Transcription Factors

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