Article
The Role of Mitochondrial Genes in Neurodegenerative Disorders.
Current neuropharmacology - 1 Jan 2022
Kumar Rajesh, Harilal Seetha, Parambi Della Grace Thomas, Kanthlal S K, Rahman Md Atiar, Alexiou Athanasios, Batiha Gaber El-Saber, Mathew Bijo
Abstract excerpt
Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease,...
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