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Article

Proteome composition and codon usage in spirochaetes: species-specific and DNA strand-specific mutational biases.

Nucleic acids research - 1 Apr 1999

Lafay B, Lloyd A T, McLean M J, Devine K M, Sharp P M, Wolfe K H

Abstract excerpt

The genomes of the spirochaetes Borrelia burgdorferi and Treponema pallidum show strong strand-specific skews in nucleotide composition, with the leading strand in replication being richer in G and T than the lagging strand in both species. This mutation bias results in codon usage and amino acid composition patterns that are significantly different between genes encoded on the two strands, in both species. There...

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Identifiers

PMID: 10075995
DOI: 10.1093/nar/27.7.1642
PMCID: PMC148367

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