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Article

Expression of alternatively spliced mdm2 transcripts correlates with stabilized wild-type p53 protein in human glioblastoma cells

15 Mar 1999

Abstract excerpt

A puzzling finding in various human tumors, including glioblastoma multiforme (GBM), is the stabilization of wild-type (wt) p53 protein. The biological significance of this phenomenon and the mechanism by which it occurs are unexplained. Recent reports have revealed that mdm2 exerts its negative regulation on the p53 signal by directly binding p53 protein and thereby instigating its proteasomal degradation. mdm2...

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PMID: 10074928
DOI: 10.1002/(sici)1097-0215(19990315)80:6<930::aid-ijc20>3.0.co;2-m

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