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Article

Binding of interleukin-13 and interleukin-4 to the interleukin (IL)-4/IL-13 receptor of human synovial fibroblasts.

Journal of receptor and signal transduction research - 1 Jan 2000

Lutz R A, Feng N, Moser R

Abstract excerpt

Synovial fibroblasts expressed transcripts for IL-4R alpha, and IL-13R alpha 1 and IL-13R alpha 2. Using weighted nonlinear computer modeling of the data from equilibrium binding studies, a 2 bindings sites model fitted the data best. After occupation of the shared high affinity receptors by the non-signaling, double mutant IL-4(121)R-->D, 124Y-->D (RY-IL-4) the high affinity binding of IL-13 could be abolished....

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Identifiers

PMID: 10071757
DOI: 10.3109/10799899909036644

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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