Article
The pathogenesis of ulnar polydactyly in humans.
The Journal of hand surgery, European volume - 1 Nov 2013
Al-Qattan M M, Al-Motairi M I
Abstract excerpt
The pathogenesis of ulnar polydactyly in humans is not known. There are numerous syndromes that are associated with ulnar polydactyly. We have noted that the genetic defects in these syndromes lead to a disturbance of the normal balance between the two forms of the Gli3 protein (the active and repressor forms of Gli3, which are known as Gli3-A and Gli3-R, respectively), leading to a relative increase in the...
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