Article
Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2013
Lu Yong-Chen, Yao Xin, Li Yong F, El-Gamil Mona, Dudley Mark E, Yang James C, Almeida Jorge R, Douek Daniel C, Samuels Yardena, Rosenberg Steven A, Robbins Paul F
Abstract excerpt
Adoptive cell therapy with tumor-infiltrating lymphocytes (TILs) represents an effective treatment for patients with metastatic melanoma. However, most of the Ag targets recognized by effective melanoma-reactive TILs remain elusive. In this study, patient 2369 experienced a complete response, including regressions of bulky liver tumor masses, ongoing beyond 7 y following adoptive TIL transfer. The screening of a...
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