Article
Telomere loss in somatic cells of Drosophila causes cell cycle arrest and apoptosis.
Genetics - 1 Mar 1999
Ahmad K, Golic K G
Abstract excerpt
Checkpoint mechanisms that respond to DNA damage in the mitotic cell cycle are necessary to maintain the fidelity of chromosome transmission. These mechanisms must be able to distinguish the normal telomeres of linear chromosomes from double-strand break damage. However, on several occasions, Drosophila chromosomes that lack their normal telomeric DNA have been recovered, raising the issue of whether Drosophila...
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