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Article

Evolution by small steps and rugged landscapes in the RNA virus phi6.

Genetics - 1 Mar 1999

Burch C L, Chao L

Abstract excerpt

Fisher's geometric model of adaptive evolution argues that adaptive evolution should generally result from the substitution of many mutations of small effect because advantageous mutations of small effect should be more common than those of large effect. However, evidence for both evolution by small steps and for Fisher's model has been mixed. Here we report supporting results from a new experimental test of the...

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Identifiers

PMID: 10049911
DOI: 10.1093/genetics/151.3.921
PMCID: PMC1460516

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Source receipt: pubmed, retrieved 7 Sept 2026.

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