Article
Heterogeneous adaptive trajectories of small populations on complex fitness landscapes.
PloS one - 5 Mar 2008
Rozen Daniel E, Habets Michelle G J L, Handel Andreas, de Visser J Arjan G M
Abstract excerpt
BACKGROUND: Small populations are thought to be adaptively handicapped, not only because they suffer more from deleterious mutations but also because they have limited access to new beneficial mutations, particularly those conferring large benefits. METHODOLOGY/PRINCIPAL FINDINGS: Here, we test this widely held conjecture using both simulations and experiments with small and large bacterial populations evolving...
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