Article
Experimental estimate of the abundance and effects of nearly neutral mutations in the RNA virus phi 6.
Genetics - 1 May 2007
Burch Christina L, Guyader Sebastien, Samarov Daniel, Shen Haipeng
Abstract excerpt
Although the frequency and effects of neutral and nearly neutral mutations are critical to evolutionary patterns and processes governed by genetic drift, the small effects of such mutations make them difficult to study empirically. Here we present the results of a mutation-accumulation experiment designed to assess the frequencies of deleterious mutations with undetectable effects. We promoted the accumulation of...
Topics
- Genome, Viral
- Mutation
- RNA Viruses
- Regression Analysis
- Selection, Genetic
- Sequence Analysis, DNA