Article
Disrupted retinal development in the embryonic belly spot and tail mutant mouse.
Developmental biology - 1 Mar 1999
Tang Q, Rice D S, Goldowitz D
Abstract excerpt
The Belly spot and tail (Bst) semidominant mutation, mapped to mouse Chromosome 16, leads to developmental defects of the eye, skeleton, and coat pigmentation. In the eye, the mutant phenotype is characterized by the presence of retinal colobomas, a paucity of retinal ganglion cells, and axon misrouting. The severity of defects in the Bst/+ retina is variable among individuals and is often asymmetric. In order to...
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