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Article

An interluekin 1B allele, which correlates with a high secretor phenotype, is associated with diabetic nephropathy.

Cytokine - 1 Dec 1998

Loughrey B V, Maxwell A P, Fogarty D G, Middleton D, Harron J C, Patterson C C, Darke C, Savage D A

Abstract excerpt

Induction of interleukin 1 activates vascular endothelial and kidney mesangial cells, and increases production of type IV (basement membrane) collagen. Hence, genes within the interleukin 1 gene cluster are potential candidates in the pathogenesis of diabetic nephropathy. In a previously validated case-control study from Northern Ireland, consisting of 95 patients with insulin-dependent (type 1) diabetes and...

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Source

Identifiers

PMID: 10049523
DOI: 10.1006/cyto.1998.0388

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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