Article
Atherogenic vascular and lipid phenotypes in young patients with Type 1 diabetes are associated with diabetes high-risk HLA genotype.
American journal of physiology. Heart and circulatory physiology - 1 Nov 2007
Odermarsky Michal, Nilsson Anita, Lernmark Ake, Sjöblad Sture, Liuba Petru
Abstract excerpt
Expression of human leukocyte antigen (HLA) class II molecules on islet endothelial cells is a central vascular event in the pathogenesis of Type 1 diabetes. Previous studies demonstrated the ability of other vascular endothelial cells to express HLA and thereby to process islet autoantigens on their surface. We investigated whether the HLA-DQ2/8 genotype, which confers the highest risk for Type 1 diabetes, is...
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