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Article

Clonality of Isolated Eosinophils in the Hypereosinophilic Syndrome

1 Mar 1999

Abstract excerpt

The idiopathic hypereosinophilic syndrome (IHES) is a rare disorder characterized by unexplained, persistent eosinophilia associated with multiple organ dysfunction due to eosinophilic tissue infiltration. In the absence of karyotypic abnormalities, there is no specific test to detect clonal eosinophilia in IHES. Analysis of X-chromosome inactivation patterns can be used to determine whether proliferative...

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PMID: 10029594
DOI: 10.1182/blood.v93.5.1651

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