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Article

Idiopathic hypereosinophilia is clonal disorder? Clonality identified by targeted sequencing.

PloS one - 1 Jan 2017

Lee Jee-Soo, Seo Heewon, Im Kyongok, Park Si Nae, Kim Sung-Min, Lee Eun Kyoung, Kim Jung-Ah, Lee Joon-Hee, Kwon Sunghoon, Kim Miyoung, Koh Insong, Hwang Seungwoo, Park Heung-Woo, Kang Hye-Ryun, Park Kyoung Soo, Kim Ju Han, Lee Dong Soon

Abstract excerpt

Idiopathic hypereosinophilia (IHE)/idiopathic hypereosinophilic syndrome (IHES) has been defined by a persistent elevation of the blood eosinophil count exceeding 1.5×103/μL, without evidence of reactive or clonal causes. While T-cell clonality assessment has been recommended for unexplained hypereosinophilia, this approach is not often applied to routine practice in the clinic. We hypothesized that the clonality...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29088303
DOI: 10.1371/journal.pone.0185602
PMCID: PMC5663336

Genes

NOTCH1
GATA2
MAPK1
RUNX1
BRD4
EGR2
FAT4
FLT3
JAK2
MPL
PTEN
SCRIB
STAG2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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