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Article

Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases.

Cell - 5 Feb 1999

Holmes A M, Haber J E

Abstract excerpt

Mitotic double-strand break (DSB)-induced gene conversion at MAT in Saccharomyces cerevisiae was analyzed molecularly in mutant strains thermosensitive for essential replication factors. The processivity cofactors PCNA and RFC are essential even to synthesize as little as 30 nucleotides following strand invasion. Both PCNA-associated DNA polymerases delta and epsilon are important for gene conversion, though a...

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Source

Identifiers

PMID: 10025407
DOI: 10.1016/s0092-8674(00)80554-1

Genes

PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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