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Article

Mismatch tolerance by DNA polymerase Pol4 in the course of nonhomologous end joining in Saccharomyces cerevisiae.

Genetics - 1 Apr 2006

Pardo Benjamin, Ma Emilie, Marcand Stéphane

Abstract excerpt

In yeast, the nonhomologous end joining pathway (NHEJ) mobilizes the DNA polymerase Pol4 to repair DNA double-strand breaks when gap filling is required prior to ligation. Using telomere-telomere fusions caused by loss of the telomeric protein Rap1 and double-strand break repair on transformed DNA as assays for NHEJ between fully uncohesive ends, we show that Pol4 is able to extend a 3'-end whose last bases are...

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Share to DNA-Directed DNA Polymerase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Recombination, Genetic

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Source

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Identifiers

PMID: 16452137
DOI: 10.1534/genetics.105.053512
PMCID: PMC1456414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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