Article
Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.
Lancet (London, England) - 2 Jan 1999
Stankovic T, Weber P, Stewart G, Bedenham T, Murray J, Byrd P J, Moss P A, Taylor A M
Abstract excerpt
BACKGROUND: Patients with the inherited disorder ataxia telangiectasia (A-T) have an increased susceptibility to lymphoid malignancies. In these patients mutations affect both alleles of the A-T gene (ATM). We have looked for mutations in the ATM gene in sporadic cases of B-cell chronic lymphocytic leukaemia (B-CLL). METHODS: 32 cases of B-CLL were analysed by restriction endonuclease fingerprinting to detect...
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