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Article

Why are there so few resistance-associated mutations in insecticide target genes?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Oct 1998

ffrench-Constant R H, Pittendrigh B, Vaughan A, Anthony N

Abstract excerpt

The genes encoding the three major targets of conventional insecticides are: Rdl, which encodes a gamma-aminobutyric acid receptor subunit (RDL); para, which encodes a voltage-gated sodium channel (PARA); and Ace, which encodes insect acetylcholinesterase (AChE). Interestingly, despite the complexity of the encoded receptors or enzymes, very few amino acid residues are replaced in different resistant insects: one...

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Identifiers

PMID: 10021768
DOI: 10.1098/rstb.1998.0319
PMCID: PMC1692388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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