Article

A Differentially Methylated CpG Site in the <i>IL4</i> Gene Associated with Anti-FVIII Inhibitor Antibody Development in Hemophilia A

2019-02-14

Abstract excerpt

Hemophilia A is the most common clotting disorder in humans. It affects one in five thousand live-born children. Mutations in the X-chromosome linked F8 gene lead to the deficiency of circulating factor VIII (FVIII). The defect is characterized by severe bleeding. The standard therapy is to replace the deficient factor intravenously. The main adverse event of the therapy is the development of anti-FVIII inhibitor...

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Literature Corpus work: fffcb2a0-9850-5a63-b7c3-9b503f7228d2
DOI: 10.1101/550566

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