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Article

Whole-exome sequencing to identify genetic risk variants underlying inhibitor development in severe hemophilia A patients.

Blood - 9 Jun 2016

Gorski Marcin M, Blighe Kevin, Lotta Luca A, Pappalardo Emanuela, Garagiola Isabella, Mancini Ilaria, Mancuso Maria Elisa, Fasulo Maria Rosaria, Santagostino Elena, Peyvandi Flora

Abstract excerpt

The development of neutralizing antibodies (inhibitors) against coagulation factor VIII (FVIII) is the most problematic and costly complication of FVIII replacement therapy that affects up to 30% of previously untreated patients with severe hemophilia A. The development of inhibitors is a multifactorial complication involving environmental and genetic factors. Among the latter, F8 gene mutations, ethnicity,...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to High-Throughput Nucleotide Sequencing

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Source

Identifiers

PMID: 27060170
DOI: 10.1182/blood-2015-12-685735

Genes

LCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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