Article
Therapeutically actionable PAK4 is amplified, overexpressed and involved in bladder cancer progression
2019-08-20
Abstract excerpt
Muscle-invasive bladder carcinomas (MIBCs) are aggressive genitourinary malignancies. Disease incidence and survival rates vary based on aggressiveness and treatment options. Metastatic urothelial carcinoma of the bladder is generally incurable by current chemotherapy and leads to early mortality. For a minority (∼20%) of patients, T-cell checkpoint inhibitors provide durable benefits following prior platinum ther...
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Identifiers and source
- Literature Corpus work
- ff85e7ed-0db9-5483-96f7-f509ecb0725c
- DOI
- 10.1101/740316