Article
Emerging therapeutic targets in bladder cancer.
Cancer treatment reviews - 1 Feb 2015
Carneiro Benedito A, Meeks Joshua J, Kuzel Timothy M, Scaranti Mariana, Abdulkadir Sarki A, Giles Francis J
Abstract excerpt
Treatment of muscle invasive urothelial bladder carcinoma (BCa) remains a major challenge. Comprehensive genomic profiling of tumors and identification of driver mutations may reveal new therapeutic targets. This manuscript discusses relevant molecular drivers of the malignant phenotype and agents with therapeutic potential in BCa. Small molecule pan-FGFR inhibitors have shown encouraging efficacy and safety...
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