Article
Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer.
Cancer investigation - 1 Dec 2023
Celik Serdar, Aktas Tekincan, Gokbayrak Ozde, Erol Aylin, Yorukoglu Kutsal, Yilmaz Batuhan, Sari Hilmi, Altun Zekiye, Mungan Mehmet Ugur, Celebi Ilhan, Aslan Guven, Aktas Safiye
Abstract excerpt
The aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving phosphatidylinositol-3-OH kinase (PIK3)/AKT/mammalian target of rapamycin (mTOR) signaling and DNA damage repair (DDR) pathways for personalized treatment in patients with non-muscle invasive bladder cancer (NMIBC). Alterations of these pathways were observed in 89.5% and 100% of patients,...
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