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A preclinical model of Brugada syndrome using CRISPR Repair in human cardiomyocytes from induced pluripotent stem cells: plattform for drug screening

2022-03-30

Abstract excerpt

<h4>Aims: </h4>: Gene variants the calcium channels have been associated with Brugada syndrome (BrS). The investigation of the human cellular phenotype and the use of drugs for BrS is still lacking. Methods and results: This study recruited cells from a BrS patient carrying a missense variant (c.425C>T/p.S142F) in CACNB2 with uncertain significance as well as from three healthy persons. Human-induced pluripotent s...

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Literature Corpus work
ff111412-1f6c-50a3-af04-b1bba578cdcc
DOI
10.22541/au.164864642.28281903/v1
Open publication

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A preclinical model of Brugada syndrome using CRISPR Repair in human cardiomyocytes from induced pluripotent stem cells: plattform for drug screeningDOI 10.22541/au.164864642.28281903/v1
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