Article

Anticodon-edited tRNA enables translational readthrough of <i>COL4A5</i> premature termination codons

2025-08-09

Abstract excerpt

Alport syndrome is caused by variants in COL4A3 , COL4A4 , or COL4A5 , which encode the α3α4α5 chains of type IV collagen. These variants result in defects in the glomerular basement membrane (GBM) and impaired kidney function. Nonsense variants result in truncated proteins lacking the NC1 domain, thereby preventing proper GBM assembly and function and causing the most severe forms of the disease. Restoring ful...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: feed76e0-b425-5145-a5fc-f7a042d38480
DOI: 10.1101/2025.08.07.669229

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Anticodon-edited tRNA enables translational readthrough of <i>COL4A5</i> premature termination codonsDOI 10.1101/2025.08.07.669229Read

Aminoglycoside-induced premature termination codon readthrough of <i>COL4A5</i> nonsense mutations that cause Alport syndromeSemantic proximity Read

NanoLuc reporters identify COL4A5 nonsense mutations susceptible to drug-induced stop codon readthroughSemantic proximity Read

Engineered transfer RNAs for suppression of premature termination codonsSemantic proximity Read

Optimization of Anticodon Edited Transfer RNAs (ACE-tRNAs) Function in Translation for Suppression of Nonsense MutationsSemantic proximity Read

Anticodon Engineered Transfer RNAs (ACE-tRNAs) are a Platform Technology for Suppressing Nonsense MutationsSemantic proximity Read

Trimerization profile of type IV collagen COL4A5 exon deletion in X-linked Alport syndrome.Semantic proximity Read

Efficient Suppression of Endogenous CFTR Nonsense Mutations Using Anticodon Engineered Transfer RNAsSemantic proximity Read

Ataluren Suppresses a Premature Termination Codon in an MPS I-H MouseSemantic proximity Read

ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosisSemantic proximity Read

Efficient suppression of endogenous CFTR nonsense mutations using anticodon-engineered transfer RNAsSemantic proximity Read

Single anticodon-edited tRNA therapy targeting highly prevalent Arg>Ter premature termination codons causing inherited retinal diseasesSemantic proximity Read

New frontiers to cure Alport syndrome: COL4A3 and COL4A5 gene editing in podocyte-lineage cells.Semantic proximity Read