Article

Bezisterim-associated anti-inflammatory epigenetic modulation of age acceleration and Alzheimer’s disease genes

2025-10-22

Abstract excerpt

Treatments with the ability to slow or reduce biological age have therapeutic potential in diseases of aging, including late-onset Alzheimer’s disease (AD). We previously reported that bezisterim, a novel anti-inflammatory insulin sensitizer, modulated epigenetic age acceleration (EAA) in a randomized, placebo-controlled, 30-week AD trial. Here, we expand on those findings through integrative mechanistic analyses...

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Literature Corpus work: fed869e4-6fac-57c6-a898-4b8abe9fe840
DOI: 10.1101/2025.10.20.25338385

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