Article

Spatial Transcriptomics Reveals that the Local Immune Response to Placental Guinea Pig Cytomegalovirus Infection is Driven by Chemokine Signaling

2025-08-02

Abstract excerpt

Cytomegalovirus infection can disrupt placental development and function either by directly infecting placental cells or by eliciting a pathogenic immune response. The relative contributions of these two mechanisms to adverse pregnancy outcomes remains poorly understood. In this study, we used spatial transcriptomics to quantify host and viral gene expression at the maternal-fetal interface at near single-cell res...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fed25d56-cdcc-5493-81e7-fe6d84dfebd9
DOI: 10.1101/2025.08.01.668085

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatial Transcriptomics Reveals that the Local Immune Response to Placental Guinea Pig Cytomegalovirus Infection is Driven by Chemokine SignalingDOI 10.1101/2025.08.01.668085Read

SARS-CoV-2 niches in human placenta revealed by spatial transcriptomicsSemantic proximity Read

Spatial proteomics reveals phenotypic and functional differences in T cell and macrophage subsets during villitis of unknown etiologySemantic proximity Read

Resolving the gene expression maps of human first-trimester chorionic villi with spatial transcriptomeSemantic proximity Read

Distinct immune responses to HIV and CMV in Hofbauer cells across gestation highlight evolving placental immune dynamicsSemantic proximity Read

Genome-wide analysis of the transcriptional response to porcine reproductive and respiratory syndrome virus infection at the maternal/fetal interface and in the fetusSemantic proximity Read

Viral-Immune Cell Interactions at the Maternal-Fetal Interface in Human PregnancySemantic proximity Read

PorSignDB: a database of <i>in vivo</i> perturbation signatures for dissecting clinical outcome of PCV2 infectionSemantic proximity Read

Single-cell Analysis of Paired FFPE Placentas Reveals Trophoblast Reprogramming and Immune Dysregulation in Chronic Villitis of Unknown EtiologySemantic proximity Read

Dual Analysis of the Murine Cytomegalovirus and Host Cell Transcriptomes Reveal New Aspects of the Virus-Host Cell InterfaceSemantic proximity Read

A single-cell transcriptomic atlas of the pigtail macaque placenta in late gestationSemantic proximity Read

Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsiaSemantic proximity Read

Differential responses in placenta and fetal thymus at 12 days post infection elucidate mechanisms of viral level and fetal compromise following PRRSV2 infectionSemantic proximity Read