Article

Dose-response modelling of endemic coronavirus and SARS-CoV-2: human challenge trials reveal the individual variation in susceptibility

2022-04-16

Abstract excerpt

We propose a mathematical framework to analyze and interpret the outcomes of human challenge trials. We present plausible infection risks with HCoV-229E and SARS-CoV-2 over a wide range of infectious dose, and suggest ways to improve the design of future trials and to translate its outcomes to the general population. <h4>One sentence summary</h4> We rephrase dose-response models in terms of heterogeneity in suscep...

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Literature Corpus work: fe8422a4-ac73-556d-bcf9-d01e37ba5631
DOI: 10.1101/2022.04.07.22273549

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