Article

Leveraging infectious disease models to interpret randomized controlled trials: controlling enteric pathogen transmission through water, sanitation, and hygiene interventions

2022-04-29

Abstract excerpt

Randomized controlled trials (RCTs), which evaluate hypotheses in specific contexts, are often considered the gold standard of evidence for infectious disease interventions, but their results cannot immediately generalize to other contexts. Mechanistic models are one approach to generalizing findings between contexts, but infectious disease transmission models are not immediately suited for analyzing RCTs, since t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8dcabff8-e2d0-5e75-a233-d768c2ec608d
DOI: 10.1101/2022.04.28.22274441

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Leveraging infectious disease models to interpret randomized controlled trials: controlling enteric pathogen transmission through water, sanitation, and hygiene interventionsDOI 10.1101/2022.04.28.22274441Read

Understanding the effectiveness of water, sanitation, and hygiene interventions: a counterfactual simulation approach to generalizing the outcomes of intervention trialsSemantic proximity Read

Some principles for using epidemiologic study results to parameterize transmission modelsSemantic proximity Read

Leveraging seasonal dynamics to identify the strength of disease transmission along multiple environmental pathwaysSemantic proximity Read

Influence of temperature and precipitation on the effectiveness of water, sanitation, and handwashing interventions against childhood diarrheal disease in rural Bangladesh: a re-analysis of a randomized control trialSemantic proximity Read

Using simulated infectious disease outbreaks to guide the design of individually randomized vaccine trialsSemantic proximity Read

Leveraging pathogen sequence and contact tracing data to enhance vaccine trials in emerging epidemicsSemantic proximity Read

A cost-benefit analysis of using wastewater monitoring to guide typhoid vaccine campaignsSemantic proximity Read

The required size of cluster randomized trials of non-pharmaceutical interventions in epidemic settingsSemantic proximity Read

Parallel Trends in an Unparalleled Pandemic Difference-in-differences for infectious disease policy evaluationSemantic proximity Read

Leveraging mathematical models of disease dynamics and machine learning to improve development of novel malaria interventionsSemantic proximity Read

Mathematical modeling of malaria transmission dynamics in children under five years of age facing innovative interventions in the Democratic Republic of the CongoSemantic proximity Read

A Simulation Study of Sampling in Difficult Settings: Statistical Superiority of Little-Used methodSemantic proximity Read