Article

circAβ-a RNA encoded Aβ175—the hidden driver of β-amyloid plaque formation and deposition in sporadic Alzheimer’s disease

2025-01-18

Abstract excerpt

Mechanisms that trigger Aβ production in sporadic Alzheimer’s disease are still obscure. We recently reported the expression of a human circular RNA (circAβ-a) encoded Aβ peptide precursor variant (Aβ175). Presently, we demonstrated that AAV9 virus-expressed circAβ-a gave rise to extensive extracellular Aβ plaque depositions and microglial activation in mouse brain; this recapitulates critical pathogenic hallmarks...

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Literature Corpus work: d00f8f54-6ecb-51a4-9af4-720d93752cb5
DOI: 10.1101/2025.01.18.633698

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