Thinking Outside the Box: Indirect Myc Modulation in Canine B-Cell Lymphoma

Abstract excerpt

B-cell lymphomas (BCL) is the most frequent hematological cancer in dogs. Treatment typically consists of chemotherapy, with CHOP-based protocols. However, outcome remains generally poor, urging the exploration of new therapeutic strategies with a targeted approach. Myc tran-scription factor plays a crucial role in regulating cellular processes and its dysregulation is im-plicated in numerous human and canine mali...

Topics

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• CAR-T cell therapy research
• Germinal Center
• Immunoglobulin Heavy Chains
• Interferon Regulatory Factors
• Lymphoma, B-Cell
• Lymphoma Diagnosis and Treatment
• Protein Degradation and Inhibitors
• Veterinary Oncology Research

Identifiers and source

Literature Corpus work

fd85da87-d0c2-5215-83d3-e1934d553967

DOI

10.20944/preprints202404.1830.v1