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Transcriptomic profiling in canine B-cell lymphoma supports a synergistic effect of BTK and PI3K inhibitors

25 Apr 2025

Abstract excerpt

Introduction: B-cell receptor (BCR) signaling has revealed itself as a critical pathway in the pathogenesis of B-cell lymphoma. Within this pathway, the inhibition of Bruton's tyrosine kinase (BTK) or Phosphoinositide 3-kinases (PI3Ks) alone presents encouraging efficacy in the treatment of certain both canine and human hematological malignancies. Methods: Here we characterized the effects of the BTK inhibitor...

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PMID: 40351764
DOI: 10.3389/fvets.2025.1577028

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