Article

PINK1 regulated basal mitophagy is evident in skeletal muscles

2023-11-09

Abstract excerpt

PINK1, mutated in familial forms of Parkinson’s disease, initiates mitophagy following mitochondrial depolarization. However, it is difficult to monitor this pathway physiologically in mice as loss of PINK1 does not alter basal mitophagy levels in most tissues. To further characterize this pathway in vivo , we used mito -QC mice in which loss of PINK1 was combined with the mitochondrial-associated POLG D257A mu...

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Literature Corpus work: fd76741a-dd27-533f-959b-accc3c52944a
DOI: 10.1101/2023.11.09.566402

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