Article

Basal mitophagy is widespread in <i>Drosophila</i> but minimally affected by loss of Pink1 or parkin

2018-01-12

Abstract excerpt

Parkinson’s disease factors, PINK1 and parkin, are strongly implicated in stress-induced mitophagy in vitro, but little is known about their impact on basal mitophagy in vivo . We generated transgenic Drosophila expressing fluorescent mitophagy reporters to evaluate the impact of Pink1/parkin mutations on basal mitophagy under physiological conditions. We find that mitophagy is readily detectable and abundant i...

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Literature Corpus work: 829b6395-19cf-5495-ba22-6952e6d3692f
DOI: 10.1101/235077

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