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Mitophagy reporter mouse analysis reveals increased mitophagy activity in disuse‐induced muscle atrophy

2 May 2021

Abstract excerpt

Muscle disuse induces atrophy through increased reactive oxygen species (ROS) released from damaged mitochondria. Mitophagy, the autophagic degradation of mitochondria, is associated with increased ROS production. However, the mitophagy activity status during disuse-induced muscle atrophy has been a subject of debate. Here, we developed a new mitophagy reporter mouse line to examine how disuse affected mitophagy...

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PMID: 33934360
DOI: 10.1002/jcp.30404

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