Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation.

eLife - 28 Nov 2024

Mac Thi Thom, Fauquier Teddy, Jullien Nicolas, Romanet Pauline, Etchevers Heather, Barlier Anne, Castinetti Frederic, Brue Thierry

Abstract excerpt

Deficient Anterior pituitary with common Variable Immune Deficiency (DAVID) syndrome results from NFKB2 heterozygous mutations, causing adrenocorticotropic hormone deficiency (ACTHD) and primary hypogammaglobulinemia. While NFKB signaling plays a crucial role in the immune system, its connection to endocrine symptoms is unclear. We established a human disease model to investigate the role of NFKB2 in pituitary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adrenal Insufficiency
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Mutation

Share to Organoids

Share to Pituitary Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 39607428
DOI: 10.7554/eLife.90875
PMCID: PMC11604219

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation.PMID 39607428Read ↗

Modeling corticotroph deficiency with pituitary organoids supports the functional role of <i>NFKB2</i> in human pituitary differentiationSemantic proximity Read ↗

Mutations in NFKB2 and potential genetic heterogeneity in patients with DAVID syndrome, having variable endocrine and immune deficiencies.Semantic proximity Read ↗

Transcriptome and methylome analysis reveals three cellular origins of pituitary tumorsSemantic proximity Read ↗

Deficient anterior pituitary with common variable immune deficiency (DAVID syndrome): a new case and literature reports.Semantic proximity Read ↗

A Case Report of Hypoglycemia and Hypogammaglobulinemia: DAVID Syndrome in a Patient With a Novel NFKB2 MutationSemantic proximity Read ↗

Pituitary stalk interruption syndrome is characterized by genetic heterogeneity.Semantic proximity Read ↗

Clinical integration and application of the 2022 WHO pituitary tumor classificationSemantic proximity Read ↗

Pituitary gland development and disease: from stem cell to hormone production.Semantic proximity Read ↗

Pangenomic Classification of Pituitary Neuroendocrine Tumors.Semantic proximity Read ↗

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis.Semantic proximity Read ↗

Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary DevelopmentSemantic proximity Read ↗

Novel genes and variants associated with congenital pituitary hormone deficiency in the era of next-generation sequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.