Article

Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases

2024-06-05

Abstract excerpt

<title>Abstract</title> <p>Arrhythmogenic cardiomyopathy (AC) is a severe heart condition that can be fatal during intense exercise or in pregnant women. It is induced by mutation (e.g. R2834H) of the carboxyterminus tail of desmoplakin (DP CT), but the lack of knowledge on this region limits the discovery of therapeutic compounds. Here, we have created 3D models of DP CT which show the structural effects of AC-i...

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Literature Corpus work: fd3afe86-6221-5a7c-b749-d7aa7487503d
DOI: 10.21203/rs.3.rs-4455056/v1

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