Article

Next-Generation Sequencing Identified Novel Desmoplakin Frame-shift Variant in Patients with Arrhythmogenic Cardiomyopathy

2020-01-30

Abstract excerpt

<title>Abstract</title> <p>Background: Arrhythmogenic cardiomyopathy (AC) is one of the leading causes for sudden cardiac death (SCD). Recent studies have identified mutations in cardiac desmosomes as key players in the pathogenesis of AC. However, the specific etiology in individual families remains largely unknown. <h4>Methods:</h4> A 4-generation family presenting with syncope, lethal ventricular arrhythmia an...

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Literature Corpus work: f7b1ac0d-3255-54f9-b147-d2e8f6b1af13
DOI: 10.21203/rs.2.14689/v4

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