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Article

New insights into the molecular basis of desmoplakin- and desmin-related cardiomyopathies.

Journal of cell science - 1 Dec 2006

Lapouge Karine, Fontao Lionel, Champliaud Marie-France, Jaunin Fabienne, Frias Miguel A, Favre Bertrand, Paulin Denise, Green Kathleen J, Borradori Luca

Abstract excerpt

Desmosomes are intercellular adhesive complexes that anchor the intermediate filament cytoskeleton to the cell membrane in epithelia and cardiac muscle cells. The desmosomal component desmoplakin plays a key role in tethering various intermediate filament networks through its C-terminal plakin repeat domain. To gain better insight into the cytoskeletal organization of cardiomyocytes, we investigated the...

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Identifiers

PMID: 17105773
DOI: 10.1242/jcs.03255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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New insights into the molecular basis of desmoplakin- and desmin-related cardiomyopathies.PMID 17105773Read ↗

The nonlinear structure of the desmoplakin plakin domain and the effects of cardiomyopathy-linked mutations.Semantic proximity Read ↗

Missense Mutations in Desmoplakin Plakin Repeat Domains Have Dramatic Effects on Domain Structure and Function.Semantic proximity Read ↗

Desmoplakin loss leads to PKC-dependent insertion of series sarcomeres and contractile dysfunction in cardiomyocytesSemantic proximity Read ↗

Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseasesSemantic proximity Read ↗

Desminopathies: pathology and mechanisms.Semantic proximity Read ↗

Desmosomal Dysfunction due to Mutations in Desmoplakin Causes Arrhythmogenic Right Ventricular Dysplasia/CardiomyopathySemantic proximity Read ↗

Desmoplakin CSM models unravel mechanisms regulating the binding to intermediate filaments and putative therapeutics for cardiocutaneous diseases.Semantic proximity Read ↗

Molecular abnormalities of the desmosomal protein desmoplakin in human disease.Semantic proximity Read ↗

Recessive mutation in desmoplakin disrupts desmoplakin-intermediate filament interactions and causes dilated cardiomyopathy, woolly hair and keratoderma.Semantic proximity Read ↗

Desmoplakin Cardiomyopathy: Comprehensive Review of an Increasingly Recognized EntitySemantic proximity Read ↗

Arrhythmogenic Right Ventricular Cardiomyopathy Plakophilin-2 Mutations Disrupt Desmosome Assembly and StabilitySemantic proximity Read ↗

A myopathy-linked desmin mutation perturbs striated muscle actin filament architecture.Semantic proximity Read ↗

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