Targeting HECTD3-IKKα axis inhibits inflammation-related metastasis

Abstract excerpt

<title>Abstract</title> <p>Metastasis is the leading cause of cancer-related death. Surgery is a common intervention for most primary solid tumors; however, surgical trauma-related systemic inflammation facilitates distant tumor metastasis by increasing the spread and adhesion of tumor cells to vascular endothelial cells. Currently, there are no effective interventions to prevent distant metastasis. Here, we show...

Topics

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• Cancer, Hypoxia, and Metabolism
• Cytokine Signaling Pathways and Interactions
• Histone Deacetylase Inhibitors Research
• interferon and immune responses
• Lymphatic System and Diseases
• NF-κB Signaling Pathways
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

fd2ef4f9-4ff8-559e-85c3-b3413ad68df5

DOI

10.21203/rs.3.rs-130038/v1