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Regulation by Progestins, Corticosteroids and RU486 of Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspective

2021-01-27

Abstract excerpt

<title>Abstract</title> <p>We investigated progestin and corticosteroid activation of the progesterone receptor (PR) from elephant shark (<italic>Callorhinchus milii</italic>), a cartilaginous fish belonging to the oldest group of jawed vertebrates. Comparison with human PR experiments provides insights into the evolution of steroid activation of human PR. At 1 nM steroid, elephant shark PR is activated by proges...

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Literature Corpus work
fd2717fa-d261-586c-9b97-8a35f4b596ab
DOI
10.21203/rs.3.rs-156175/v1
Open publication

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