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Transcriptional Activation of Estrogen Receptor-Alpha and Estrogen Receptor-Beta from Elephant Shark (<em>Callorhynchus milii</em>)

2025-12-09

Abstract excerpt

Humans and other terrestrial vertebrates contain two estrogen receptors (ERs), ERa and ERb. Among cartilaginous fish (sharks, rays, skates), which are jawless vertebrates that evolved about 525 million years ago, only activation by steroids of ERb orthologs has been characterized. To remedy this gap in understanding estrogen signaling in jawless vertebrates, we studied estrogen activation of orthologs of human ERa...

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Literature Corpus work
1331153a-7eb5-50f3-a93d-3867df1ab174
DOI
10.20944/preprints202512.0851.v1
Open publication

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Transcriptional Activation of Estrogen Receptor-Alpha and Estrogen Receptor-Beta from Elephant Shark (<em>Callorhynchus milii</em>)DOI 10.20944/preprints202512.0851.v1
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