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Transcriptional Activation of Estrogen Receptor-alpha and Estrogen Receptor-beta from Elephant Shark ( <i>Callorhynchus milii</i> )

2025-12-14

Abstract excerpt

Humans and other vertebrates contain two estrogen receptors (ERs), ERα and ERβ. Among cartilaginous fish (sharks, rays, skates), which are chondrichthyans that evolved about 425 million years ago, only activation by steroids of ERβ orthologs has been characterized. To remedy this gap in understanding estrogen signaling in chondrichthyans, we studied estrogen activation of orthologs of human ERα and ERβ from elepha...

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Identifiers and source

Literature Corpus work
14e9354e-327f-5c4e-982a-6d1a092d5fe8
DOI
10.64898/2025.12.11.693795
Open publication

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Transcriptional Activation of Estrogen Receptor-alpha and Estrogen Receptor-beta from Elephant Shark ( <i>Callorhynchus milii</i> )DOI 10.64898/2025.12.11.693795
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