Article

MOTS-c Attenuates Airway Barrier Dysfunction in Allergic Asthma by Inhibiting Epithelial Apoptosis via Nrf2

2024-12-27

Abstract excerpt

<h4>Background: </h4> Allergic asthma (AA), a severe chronic respiratory disease caused by chronic airway inflammation, is characterized by bronchial epithelial barrier dysfunction. The MOTS-c/Nrf2 pathway plays a protective role in various diseases by reducing inflammatory responses. In this study, we hypothesized that the MOTS-c peptide alleviates AA by upregulating Nrf2-induced antioxidant and mitochondrial pro...

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Literature Corpus work: 1bd97586-bbde-54f8-955c-e9fcf566f06a
DOI: 10.22541/au.173531348.85210662/v1

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